Sequential Tube Monoblocks

You bet it does..

Tubes, resistors and caps were made with sequential batches.

Channel balance will be off if not.

Doesn't matter when you have the only two ever made...

Totally depends on the manufacturer, but it’s ALWAYS better to have factory matched pairs or at least consecutive / close serial numbers. Hand wiring will have more chances for variance than PCB, obviously. Some manufacturers will also make minor parts swaps or circuit changes over time. Sometimes parts swaps are a necessity since they regularly go out of production (specific transistors, black gates caps, polystyrene caps etc). 

VAC’s owner auditions every component before it leaves the factory. If it doesn’t make the cut, it goes back for tuning. You can bet there’s an advantage to having this process done for a pair of mono amps, rather than cobbling together 2 units on the used market (many of VAC’s amps are switchable between stereo / mono modes).

I have had three ARC Reference 160 stereo amps and two of the same model monoblocks. The monos produced at least two years before the stereo versions and the stereo versions produced over about a year. They all sounded exactly the same… first when unbroken in, and then when broken in. I have been very impressed how exactly the same they all sounded. The monos had a lower noise floor and a wider deeper soundstage than the stereo, but the sonic character was exactly the same. 
 

So, I’m just guessing it is something unlikely to be of any importance. In theory it sounds good though.