There's a couple of things to consider here. The first is that the new tweeters are going to break in, and will sound different when that happens.
"I'm using Synergistic Research Signature 2/3, and I've hooked both the thick and thin runs of cable up to both the tweeter and the mid-woofer binding posts, individually, to confirm that everything's running as it should."
Those are 2 runs of completely different cables, they're not just thicker. Different materials are used. You need to try the speakers with either 2 runs of the exact same speaker cables, or 1 run and use the binding post jumpers.
Those cables that you have are a band aid type fix for a speaker with a very harsh tweeter like B&W. You don't need that with the 2.5's.
It wouldn't be a bad idea to list your entire system.
"I'm using Synergistic Research Signature 2/3, and I've hooked both the thick and thin runs of cable up to both the tweeter and the mid-woofer binding posts, individually, to confirm that everything's running as it should."
Those are 2 runs of completely different cables, they're not just thicker. Different materials are used. You need to try the speakers with either 2 runs of the exact same speaker cables, or 1 run and use the binding post jumpers.
Those cables that you have are a band aid type fix for a speaker with a very harsh tweeter like B&W. You don't need that with the 2.5's.
It wouldn't be a bad idea to list your entire system.