Surge protection and isolation are intended to protect you from something from somewhere else getting to the stuff you want to protect. I designed in Whole House protection at the main panel of my home and that protects two ways - between the two 110V phases that add together to provide 220V to HVAC, stoves, and other large loads like big swimming pool pumps, etc.
That does NOTHING to protect you from the start-up spike put on the line on a single 110V phase when you turn on a vacuum cleaner, table saw, refrigerator or other significant motor load anywhere inside the perimeter protection of a WHSP unit. Your HVAC Air Conditioner will often put a spike on BOTH poles because those units usually run on 220 V. the worst culprit is not the fans inside or out, but the compressor motor in the outdoor part of your system. If you look in your circuit breaker box, you will usually find several double-wide breakers with a handle that links both sides together. That will be something that uses 220V and is probably a big load that can noticeably affect your whole house.
Although some of your devices may have their own universal power adapters that will output the desired voltage to the attached equipment despite the incoming voltage, a large but purely resistive load like electric heat kicking on will drop your line voltage enough so your other equipment may still notice the effect and not be running at optimum unless you have a buck/boost AVR (automatic voltage regulation) unit like a good UPS between that big load and your sensitive devices. Just don't get an inexpensive unit that puts out anything other than pure sine wave power or you will be creating more pollution on the power line than you are isolating your stuff from. Some units even run you on batteries full time and just use the house power to charge the batteries.
Just make sure you do not run different parts of your system on multiple sources or you may have serious grounding issues. This also means that you want to avoid running some devices from the "surge only" outlets on a UPS and other devices on the "battery backup" outlets of the same UPS, or worse, from another UPS' battery supported outlets. Having a variety of ground potentials across your system can have some weird and undesired effects. This is where you want someone who can design and put together a good system isolation and protection scheme for you, not just someone who can meet local codes for safety.
Any decent sized motor load (or a poorly designed one) can also put a sharp spike on the power line when it turns on or off that can cause even more havoc. Transients are NOT your friend and are more likely to be regularly attacking you from within your home than the less likely but occasionally more devastating external hits. You want to get the best possible sound from your investment, AND protect the devices that give it to you.
I happen to use a combination of Monster Power and PanaMax line conditioner / surge suppressor devices that isolate each outlet optimally for the type of interference the connected devices are most susceptible to. There are better and newer devices out there now, but these have worked well for me.
Something I did not expect, was a hit one of my customers took recently when lightning came in on the shield wire of his fiber internet connection and took out about a dozen devices across his network. The UPS isolated the power, but routers, modems, network switches and even network cards in workstations got fried. The ISP had decided they did not want their ethernet cable grounded through the UPS, and they had not put a ground tie on the fiber cable before it went to their fiber-to-ethernet conversion box, so they replaced just about everything they had on site. Not grounding their cable at the point of entry to the building was as egregious an error as not installing a whole house surge suppression box at your main power panel. Electricity is like water - it will flow wherever it is easy to get to. Just because the fiber isolates the data signal from EMI does not mean that the cable shield, which is there for mechanical protection as well as tensile strength, cannot carry a surge onto your premises.