You guys must all have golden ears lol. I can’t hear a difference. There is sometimes (often maybe) an advantage to not wire things together as noise can travel from one device to another. I once had the hum of a plasma tv bleed through my entire system. I switched to a projector in the end.
Anyway I would think Wi-Fi would help stop noise bleed. Fiber optic would do the same. This is why I liked the old school macs with toslink out. Stopping the noise was more advantageous than the added jitter of the toslink vs USB.