If you do direct-coupling correctly, it can be very reliable. I don’t think it wise to direct couple throughout the circuit though!
The advantage of a direct-coupled cathode follower driver tube are several. First, there is more current available to provide linearity if grid current is produced by the output tube(s) (which allows for class A2 or A3 operation since both of those classes produce grid current), and no worries about Miller Effect, so very wide bandwidth (+30MHz!) is very easy (we bandwidth limit our OTL amps in the voltage amplifier section). The stability of the circuit is very high- in our OTLs (where one driver tube is controlling many triode power tube grids), bias adjustment only needs checking once every 6 months or so; often no adjustment needed. Distortion is kept in check in a way not possible if a cathode follower with coupling cap were used. We went to this circuit because its more reliable and prior to its introduction to the marketplace, OTLs generally had a reputation for being unreliable. This approach was key to making OTLs as reliable as any other tube amplifier; one of the reasons we are still in business after more than 45 years.
How this might work in an SET is a different story- yes, you need a B- supply to really pull it off, but if you want to do it with transformers you’ll have to pay that price too, since decent interstage transformers are not cheap- in fact, several times more expensive than a B- supply.
The other advantages of using a direct coupled cathode follower driver are that the driver prevents output tube conduction until the driver has warmed up and stabilized. This is likely not a concern when DHTs are used, but it is if indirectly heated, since cathode stripping can occur if the B+ is applied while the power tube is warming up.
Another advantage, probably the big one, is that small value coupling caps can be used between the voltage amplifier and the driver tube. Since coupling caps have inductance (since they are wound) no matter what materials are used they will always introduce some coloration on this account. By minimizing their value while still allowing for very wide bandwidth, the coloration they might cause is minimized and the inductive influence octaves above the audio band.
If course you could use an interstage transformer for this latter function as well; the advantage being that’s the least expensive place one could be used and most likely to win the most performance from the transformer.
At any rate, by using this approach you wind up with a very simple circuit that offers excellent linearity. One idea I’ve had for a while for an SET is taking advantage of the B- supply and building a differential amplifier for the input voltage amplifier. This would allow a proper balanced input as well as reducing distortion in that gain stage due to harmonic cancellation.
Of course if you already have a fully differential/balanced amplifier design from input to output, the advantages multiply.
We’ve been building a balanced preamp with a direct-coupled output (for which we have several patents) that uses servo control to prevent DC offsets at its output. The inputs of the preamp are direct coupled as well, but coupling caps are used between stages. The DC servo has proven to be one of the most reliable aspects of the circuit, which has been in production since 1989. During that time we simply have not seen any servo failures! The output of the preamp uses a Circlotron, like our OTLs, so there are no excessive voltages produced as the preamp warms up.
The obvious advantage is a lack of coloration at the output of the preamp (most tube preamps use a large coupling cap, from which, as pointed out earlier, colorations are unavoidable) and very wide bandwidth; to the latter point the direct coupling allows for reproduction of extremely low bass that most tube preamps won’t even acknowledge. Since the preamp uses no feedback, controlling phase shift can only be done by having bandwidth down to 1/10th the lowest frequency to be reproduced, so its good to 2Hz. If phase shift is present, the ear perceives it as a lack of impact, even though the preamp might otherwise be perfectly flat at 20Hz. By direct coupling that problem and the often tubby bass that can occur are both avoided.
So while direct coupling (with or without a servo) might seem tricky, it offers great advantages and can be extremely reliable if properly designed.