+1 to the comments by @theo about the room.
Speakers interface with the amplifier and the room. Both interfaces must be compatible.
With most speakers and short speaker cables and most solid-state amps, pairing with amplification is not a big problem. Still, amps are voiced a bit differently, and one wouldn’t want a bright amp with a bright speaker. When using tube amps, system synergy becomes more important because of their high output impedance.
As to the other interface, room acoustics are always important. Cheaper speakers in a good room will usually sound better than more costly speakers in a poor room. These differences are huge, and what can be achieved by improving room acoustics is far more important than swapping cables, DACs, or in most cases, amplifiers.