I too love the Pure Audio Project Quintet 15 speakers. I heard them with the center horn driver too, but, I would really love to hear them with the Voxativ fieldcoil driver-I have heard that driver in another system and it delivers a very vivid and lively sound. Even with four 15" drivers, my concern would be bass energy in a large room because of cancellation of the front and back output which are out of phase (this reduces bass by 6 db/octave).
This is still an excellent recommendation that is consistent with the kind of sound that would be delivered by the likes of Charney, Rethm and Volti speakers. An important reason for picking these kinds of speakers, to me, is that they can be driven by lower-powered tube amps which are my favorite kind of amp. While a SET amp might not not be ideal, given the size of the room (the Charney might be efficient enough), there are many good lower-powered pushpull amps and a few OTL amps that would work well.