For me, it's large towers preferably, running full range (not crossed over) and a couple of subwoofers.
I'm of the mind, If you like the sound of your speakers why remove part of their character and then try to replace it using the sub? Running full range you just augment the sound with the sub without taking something away first.
The reason I use subwoofers even with large speakers is because they are able to be placed where they are most effective. I like my speakers pulled way out from the wall to get the best soundstage depth, but this usually decreases bass output.
Adding subs is like adding salt to dish to to enhance the flavour of the food, it changes the whole experience. So using the subs crossover, volume and its positioning you can add the right amount of "salt" to get your system sounding its best.