I have had a 300B amplifier with a 6f6 driver for many years.
I upgraded and rebuilt it many times.
What was an essential upgrade is adding an interstage transformer between driver 300B instead of RC coupling.
My experience shows that monoblocks are not essential for good soundstage and imaging. It is enough to isolate right and left channel power supplies by LC or even by RC filter. It gives enough channel separation except sub bass that is not important for imaging. But sub bass isolation is super important for the driver to output power supply. Otherwise we get PS feedback between output and driver and as result motorboating that leads to loose bass. As a result, it is better to separate driver and output power supplies.
Another important subject is power supply capacitors quantity and quality. The same thing is important for cathode bypass capacitors.