I use Plitron isolation transformers for all sensitive electronics. These are industrial grade, not consumer-itis.
I have done a factorial Plitron/ Wall x Aftermarket Power Cord two factor experiment, (in all combinations). Source power was high quality 117VAC half a mile from the nearest commercial installation. No AC, no street lighting running in the neighbourhood. Amps Bryston, speakers Quad ESL, source vinyl.
Best sound was with Plitron isolation transformers. With Plitron, all power cords sounded the same. With wall power, more expensive cords sounded better, monotonically increasing with price (best of these aftermarket cords was $4k).
Just how good can it be? Well, comparing an isolation transformer in front of a medical grade power supply, that power is almost as good as NiCad battery (NiCads are so quiet that they fall below the noise floor of most professional test equipment). You have to listen with utmost attention to hear the difference. That is for powering the most sensitive device, the phono/pre.
Other benefits include protection from power surges. You just can’t expect a 5kg transformer (at most) in a component to protect like a 20kg transformer by the panel. The notion that ANY commercially available amp under 50K is going to protect like that is silly. Even on my big (100 lb of transformers,100 kg of inductors, 1F capacitance) brute force power supply, I use Plitron isolation.
For what it’s worth. YMMV.