Is it best to isolate??

You can overdamp but isolation helps. I use FIM cups with tungsten carbide ball bearings under my DAC and transport. Use only one with marble tile on top of the ball bearing. Based on Barry Diament's design. I have a Star Sound rack which is also very heavy and filled with steel dust. Still helped.

I was not clear, I use three but they come with a top and bottom with the ball bearing intended to be between them; I only use one piece as I have found that to sound better, as a side benefit you get twice as many with only additional ball bearings to buy.

I have never experienced "over dampening". Only with speakers, not components. Isolation will make a difference IF the situation calls for it. Heavy components, that have isolation designed into them, will likely not improve with additional treatments. Also, are you thinking of isolation from external sources OR from the same source? There is a difference.

You must decide if you like what various isolation devices will do to the sound of your system. Many say its best to isolate and I do use isolation, but I'm still not sure whether the difference they make is audible or a positive difference.

Isolating always leads to depression, or stems from it, for me..

Withe CDPs though I've found nearly anything you put under or on top of it, and what you place it onto does matter as changes will occur.

The 'flavor' of the change IMO comes from more than just those pods, cones, pucks, or balls in direct contact with the player. The rack or resting place plays as much a part too. Some simply buy platforms for players. Simple.

I like the herbie's Audio Labs wooden Ebony balls atop the iso cups so far as the best I've used. Jesus I am cheap come to think of it. $60-$75 for 3.

Like Stan said though, and I've heard from a LOT OF OTHER PEOPLE those roller cups are a viable solution.

Find those folks who allow a trial term and get startted trying 'em out.

Good luck.