I cannot imagine the "open air" approach to buliding a plinth for a 301 would be efficacious, for me at least, because what you want to suppress in a 301 is vibration and motor noise. For that it seems to me you need mass. That’s just my opinion.
So I quite agree with your choice to fill the space in the hollow plinth. But in your first post where you described what you are building, it seemed at first reading that you plan to interpose springs between the chassis of the 301 and the solid plinth you are making with MDF. It think that would not be good, to put it mildly. I'd mate the chassis to the plinth as firmly and as completely as possible. As for the choice of MDF, I never want it near the sound producing elements because my bias is it sounds muffled, or it adds a muffled coloration. But again, just my opinion.