@sns Optically isolated USB regenerators are rare beasts so not surprised you’ve not heard of em. Here’s an expensive example from Afterdark, I got a much cheaper AliX equivalent that comes highly rated from that French hifi tweakers forum. Most USB isolators/regenerators deliver a level of isolation, some superb, some not quite so good, but technically at least, as for networks, they can’t quite match the 100% galvanic isolation of optical. As to the sonic effect it has on my Harmony-based system, I’ll keep you posted.
Re I2S vs USB, your vote in favour of the Gaia’s I2S vs your system’s already sorted USB comes through loud and clear. Sounds most excellent.
I’ll keep this forum posted as to where I get to with my own comparisons in my system, which have already included an externally clocked U18 via I2S (incl with the LHY USB regen feeding it) and when I can find its AWOL DC cable, my SU6 as well. Though from experience the former beats the latter (noting the SU6 beats the U18 using its internal oscillator), whilst the externally clocked UIP over USB was comfortably better than the former with both the LaiV and R26. Also hope to try an Audio-Gd DDC with the Harmony, it was very good indeed with my R26, if not quite in the class of a loaned PhoenixUSB I compared it to.