Will one cable upgrade make a noticeable difference?

In a word, no (but neither will any other cable).

In one word,  maybe .

Latest wtf moment was when I tried a new usb cable. 

Big improvements!

When you replace the cable you must endure 400 hours of break-in time after which you then must remember what the other cable sounded like. Easy peasy.

I think you have good chance to hear a significant difference since you would have more brand synergy. The question is would you like the difference in the sound. I always take the risk and try myself. We can resell if not as hoped.

@cantorgale 

HI Cantorgale

Only today I read this question of yours. Replacing cables can be a great upgrade. The secret is to always start from the power supply, which is of fundamental importance for all HiFi/HiEnd systems. So I did and I immediately heard a big difference with a much better sound. Then one cable at a time I replaced them all and now I enjoy the music as much as possible that my system can give. It is important that all cables are of the same brand and of the same series... the synergy between them is fundamental in my opinion.

For your information, my system is as follows:

Audio Analogue Puccini Anniversary Amplifier, SME Model 10 Turntable, SME Series IV Tonearm, Sonus Faber Olympics II Speaker, Benz Micro PP1-T9 Pre-Phono, Benz Micro LP Cartridge, Lyra Titan i Cartridge (with load adjustment through 100 Ohms Audio Note resistors), Streamer/DAC Homemade with IAN CANADA parts and all cables (power, speaker, interconnect and phono from Audio Analogue Airtech series ZERO (Top). Finally, consider that for my top listens, Vinyl remains the best.

Kind regards

Alessandro