Even if you are limiting this discussion to conventional cone drivers (e.g., not considering electrostatic or planar magnetic panel speakers, bending wave drivers like MBL speakers), there are great examples of one, teo, three, and more-way speakers. No speaker is perfect in all respects and each has different strengths and weaknesses and listeners have different tastes snd priorities such that a wide range of speakers can be favored. I like the one-way, single driver systems from Songer Audio and Charney Audio. I like MANY two-ways, some conventional driver systems from the likes of Audio Note (including their near six figure fieldcoil two-way AN-E speaker) ProAc, Harbeth, Fyne, etc., and MANY three ways, particularly three-way horns.
I don’t think this particular design characteristic is determinative of sound quality.