I clean the record before play with a carbon fiber brush, and I use a brush to clean the stylus after each play. I use the LAST stylus cleaning fluid about once a month and the Oznow stylus cleaner about once a month, or when I think the sttylus has gotten some gunk on it.
This regimen, along with use of the LAST stylus preservative before each play, enabled my last stylus to play for over 1200 hrs. and still sound good.