If you keep your room appropiately clean, a dust cover isn't at all necessary IMO. If you don't keep it clean enough - why not?
I could see a big heavy dust cover being maybe appropriate if you have a cat, but then you better hope they stay away from your speakers too (some love to claw at drivers). It could also be advisable if you had a linear tracker arm with a mile of precision bearing surface to collect dust and get gummed up over time (e.g. ET 2).