r.e. Innuos
They make some excellent streamers and I just demoed their Pulsar model. My DAC has pretty much all of the available inputs and since I wanted to have the best possible results from the demo I queried Innuos directly about which is their preferred digital out. The reply from Innuos: "I would recommend using USB as the connection type - this is our specialty and I believe it is very implemented."
The Pulsar has the Phenix Lite relocker built in and it's basically a watered down version of the Denafrips Hermes using a USB pathway.
My takeaway from this is that while offering different output/input options, manufactures seem to focus their technology on a specific protocol. I think it's worthwhile to know where their focus is to maximize performance.