The complex issue is that the smaller the room the more room modes you are likely to encounter. Smaller speakers don't wake those dragons like larger speakers. These modes can cause nulls but more noticeable are the enormous peak bass outputs in very narrow bands which sound excessively boomy or irritating.
A really common example are listeners who get massive subs and then have to keep the volume too low. Clip the peak problems and then they can bring the sub up for a much smoother and more rewarding experience.
Fortunately this is the kind of problem an EQ can fix quickly and cost effectively. I am a proponent of using some balance of room acoustics including bass traps + equalizers to resolve these issues.
