Leave it on 24/7 and change the tubes every year. It's perfectly safe assuming proper ventilation and decent equipment design. The issue with digital equipment is that the clocks need to be at thermal equilibrium for optimal performance. Effectively, that means leaving them on 24/7.
If you're interested you could conduct a test. Leave the D/A powered for a week and listen, then turn it off for 48 hours. Power it up and figure out whether you can hear a difference.
If you're interested you could conduct a test. Leave the D/A powered for a week and listen, then turn it off for 48 hours. Power it up and figure out whether you can hear a difference.