Help with fatiguing sound in my PC system


I replaced my Halo Pre and Denon changer with a PS Audio DL III. I run lossless music into it from iTunes on a PC (Windows 7 64bit, core i7, 16MB RAM), I use a Pangea USB cable into a MF V-link, then go into the DAC with a Wireworld ultraviolet coax. The increased detail, clarity, resolution and extension are remarkable, but so is the amount of listening fatigue. The highs are too much, but the music sounds muffled if I add the pre-amp back. My system is profiled in the link below. I have some ideas, let the voting begin:
1 - buy an offramp or a pacecar (can't afford it!)
2 - use better USB/coax/interconnects/speaker cable
3 - apply acoustic treatments to the room
4 - use a software player (Jplay) that sits on top of iTunes
5 - buy speakers with different tweeters (Quad 22L2/Focal 826v, this is happening, but not any time soon)
6 - get a better amp (McCormack/Odyssey, distant future)
7 - tweak Windows 7/iTunes settings (WASAPI exclusive mode?!?)
8 - adjust speaker position/toe in (already did this and it helped a little)
I am thinking about trying #3/#7 next. Ideas? Thnx in advance.
realremo
Have you tried any different ICs just to see what effect they might have? Not familiar with your but ICs are one way to solve this kind of thing sometimes. IF you think your ICs might be on teh bright side and a contributor, try a pair of inexpensive used networked ICs like MIT terminator. These are the ones I know of specifically that lean more towards a fuller low end in their spectral balance.
Thanks Mapman, I will try that if the acoustic deadening I plan to do in the room doesn't help. I have always wanted to dampen my listening room, There are way too many hard surfaces.
Also considering a purchase of Jplay, the SQ improvement cannot be ignored. I don't know if I can go back to iTunes, even using WASAPI, iTunes cannot compete with the improvement Jplay makes.
Update: purchased Jplay and placed the pre back into e system, the signal from iTunes with Jplay is strong enough to retain a lot more detail compared to just running iTunes thru the pre. Using Jplay directly into the dac and amp is still too bright. Wouldn't be doing Pc audio without Jplay, it's a great piece of code...more later...
While the digital audio chain can certainly contribute fatigue, what I've personally found is that unbearable listening fatigue is more likely to come from the speakers, the amplifier, and the room.

If you are not planning to replace speakers and amplifiers for some time, then short term fix may be the room.

Does your room exhibit much in the way of slap echo?
Yes it does, and acoustic foam is next on my list. I have carpet on the floor, but the walls and ceiling are gypsum wall board (sheet rock). The room is 12x12x8. I'm planning on putting up about 100 sq ft of acoustic dampening. I have also researched the audiophellio, read some reviews, and tonight I'm more in the "save for new speakers" camp. Still researching the stello. Tomorrow night or Sunday I'll have another idea, but the acoustical treatments will happen regardless.
Whatever I do, nothing can help my 1980 "Boy" CD, I'll have to buy the 2008 remaster.