Which worse- long I/C of speaker run


Musical Fidelity had their new M250 power block amplifiers. Their pitch goes that the amp is close to the load (speaker) so to "give the amplifier excellent damping".

But this will require long 2-12 foot runs of I/C. So which is worse? Long runs of speaker cable or interconects? Will the delicate low level signal be losing information with a long I/C.

I would think the preamp would require full balanced outputs (preferably all the way through the preamp - Mike Creek was displaying such a preamp) to prevent signal loss.
Any thoughts? Thanks
cdc
Thanks Sean. Per your suggestion, I read your post on Cables 101 and found it very informative. Comforting to know that you consider my current cables pretty good. I'll try to audition some others soon.
Depends on brand/design of cable. My experience; better to run long interconnects.
Thanks for the responses. I have been out of town.
It sounds like long I/C runs can't hurt. I would stay away from shielding speaker cable and have heard the higher capacitance can ruin a power amp.
For other good speaker cables, Nordost and Analysis Plus oval 12's are other options I've been considering.