It really depends on your amp. If the two sets of terminals were made for Bi-wire then fine. (Only using one set of terminals here is fine also.) If the two terminal sets were made for two separate pairs of speakers, then I would not use both.
Secondly, whether a single bi-wire set or running two separate pairs of cables is better again depends on which cables?? A single biwire set is easier when the amp in questions only has one pair of terminals (which is what I do currently). However, I did once own a double run of cables where I had the two separate pairs combined on one spade for the amp end.
When you find bi-wire cables for sale where the bi-wire pair cost almost double a non biwire pair, it usually means it is a double run combined at the amp end. (Analysis Plus is one). If the bi-wire pair is only slightly more than a single pair, then they are most likely a single internal biwire cable (Audioquest, Straightwire and others). My double run was Audioquest even though they could have been made from a single pair.
Sometimes using a double run (2 pairs) is called "shotgun". In a shotgun setup the user will use one cable set for both (+) terminals and the other set for both (-) terminals; instead of one set for the highs and the other cable set for the lows (traditional biwire setup).