Marty is right that room resonances will be largely determined by the room dimensions, regardless of the number of subs. Careful placement of the sub or subs can help a bit, but the walls will still be the most important factors. (Like, it's very hard to reproduce a sound with a 30 foot wave in a 26 foot room, no matter where the sub is or even if there are multiple subs. On the other hand, the room will tend to emphasize sounds with 26 and 52 foot waves.)
Using multiple subs to try to reduce the impact of room resonances is difficult and not very effective, especially since the output of the subs will be reinforcing or cancelling at different frequencies as a function of how far apart they are and where they are relative to the listening position, as well as dealing with room resonance factors.
Using multiple subs to try to reduce the impact of room resonances is difficult and not very effective, especially since the output of the subs will be reinforcing or cancelling at different frequencies as a function of how far apart they are and where they are relative to the listening position, as well as dealing with room resonance factors.