Br3098,
Some of the high end audio equipment is so unreliable that almost anything can cause a change in response. In fact some equipment probably never sounds the same twice ever anyway. In this case, every change including the material used in the cover plate on the wall socket to the minutest change in listening position ,volume level etc. will make an audible difference, sounding slightly different every time a critical observation is made.
As you correctly point out, some types of equipment are specificially designed (manufacturers go to great lengths) to ensure they are largely immune and largely robust to significant changes in the operating environment.
So it really depends what equipment you are referring to or what you prefer to use. Some folks will shun robust equipment as being unresolving and favor something that is highly setup dependent (resolving). For some, setup sensitivity to a variety of factors is good proof that the equipment is highly resolving. (If a mere wall socket changes the response then said equipment must surely be able to pick up even finer details in the music than most)
It is a difference of philosophy.