Having read hundreds of posts on the sound of tubes, Im not sure there is enough agreement on what that sound is to use the term as a descriptive device. But that said, and in general, tubes can have an influence over a host of elements that collectively make sound musical. IMO, different tube component types e.g., amps and preamps, tend to impact different musical elements with lesser or greater weight. So, depending on ones priorities, there is no definitive answer as to which is preferable - tube amp or preamp. Personally, I require output power tubes to achieve the results I want.