02-07-12: NsgarchHi Neil,
Not sure what kind of sub you have, but with the ones that have both line level and speaker level inputs, the sub just 'samples' the input signal (yes, the RCA inputs too). So your preamp isn't really 'driving' the sub's amp(s) per se; so impedance mismatching that might possibly normally occur just isn't a factor.
Not sure what you mean by the word "samples" in this context. I think you might mean that the voltage level of the signal being input to the sub is divided down to a lower level which is then processed internally. But that, and any other "sampling" process you may be referring to, are irrelevant.
If the sub's line-level inputs are being used, and their input impedance is 20K for example, then the preamp has to drive that 20K load, regardless of whatever "sampling" may occur. If, as in this case, the preamp's two sets of outputs are not individually buffered, then a single output stage in the preamp has to drive the parallel combination of that 20K and the input impedance of the main power amp. That combined impedance will be less than 20K, and will affect the signals seen by both the main amp and the sub. The preamp also has to drive the interconnect cables to both destinations, and the capacitance of both cables will affect the signals seen by the main amp as well as by the sub.
Impedance matching considerations are very much a factor in that situation, or in any other situation in which a powered sub is being driven from a line-level signal source having significant output impedance. And the importance of those considerations is increased by the relatively low input impedance that subs commonly have (as Grannyring pointed out), and by the fact that both the main amp and the sub, and their interconnect cables, are driven by a common output stage if the preamp does not individually buffer the two sets of output jacks that it may provide.
Best regards,
-- Al