I have my iMac in one room connected wirelessly to an Airport Extreme base station. My music files (400GB, 1400 CD's, Apple Lossless) are in a hardrive attached to the iMac. I have an Apple TV connected to my HD television via HDMI cable, with the speakers in the TV turned off, and analogue audio output from the Apple TV routed into my Rogue preamp using Synergistic cables. I plan to either go with a DAC attached to the Apple TV via Toslink, or switch the Rougue out for a Benchmark DAC 1 Pre preamp.
As of this weekend, I can control the whole thing using an Apple iPod Touch with the newly released "Remote" application. I can also access Pandora by using a docking station connected to my second system with a mini to RCA cable.
All in all, I am very happy so far, and will be even more so once I get a DAC installed, although the RCA output is pretty good to my ears, as well as to others in this forum.
Good luck.