I truly believe the RSA Poiema's are very high quality cabling and most likely will work great in most systems. However, it is also worth noting that system matching is critical. I know RSA claims they are not a tuning cable, however there are certain factors out there, such as some speakers will not work well with silver speaker wire or cabling. I called the Cable Company and talked extensively to find out many speakers don't mate well with silver, no matter the brand. I had that unfortunate experience with the Poiema's on my Meadowlark Nighthawks, in which should never sound the way they were interracting with the silver cabling. I was told from the research done in their records Meadowlarks prefer solid core copper, etc. I switched everything out to Synergistic Research Resolution Reference X2 and am astounded. Center image and pinpoint imaging in focus... sounstage well behind the speakers, well outside the speakers, almost as wide as the walls in the room. Harmonics, timbre, in spades, yet much quieter background.
I don't want to inflame any of the RSA camp, trust me, I kept wanting them to work and get better, but well into the extended trial period it was obvious it was not a match for my speakers/system.
With that being said, if or when in question on cabling I would strongly suggest looking into the Cable Company or the like in which you can borrow 3 or 4 different companies products that are already broken in and compare as to what works best with your system.