MDF is basically wood dust and glue. The reason MDF has no purchase when you screw into it is because the glue is the most expensive component, and the manufacturers only put enough in to just hold the wood dust together and no more. It is designed as a very low cost material. I worked for a number of years in the timber industry.
When you buy something like DAS plinth you are buying weetbix wrapped in xmas paper.
This doesn’t necessarily mean it will sound bad, it simply means you are buying a plinth that’s full of wood dust and glue.
Personally on my 301 I used a hybrid of compressed bamboo ply and birch ply. Bamboo ply is harder than Maple, can be CNC’d ( I did mine myself ) and provides a stable platform that won’t warp over time. It is not pretty though, which appears to be important for some folk.
I do not use wood veneers because they are not stable and eventually you can see all the joins and I personally can’t stand that. If I wanted a wood finish I would do a shindo style laminated solid wood block plinth.