I don't recall that it was anything unusual about selecting Escrow.com as the payment method and then signing up for a Escrow.com account. The only issue was that any buyer also had to set up an account with Escrow.com and send the money thru them. Anyone that has previously set up a PayPal account or an online account with a bank should not have any issue with following the instructions.
Is there anything specific that has you confused or concerned?
Feel free to PM me.