Is it possible to be an audiophile and be happy with what you have

Very content right now with my system.  One major upgrade in recent years.  Would love to experiment more with different cables but I'm happy enough with the sound now that I realize it might be futile/pointless.  Probably will try to tweak a bit anyway down the road--and why not?

Of course.

Yes, absolutely, as long as you replace all of your electronics every three to five years and your speakers every five to ten years. 

I am one of those who has little problem staying put for long periods, though it may take a while to reach that sweet spot of system synergy.

I did not change my system in the U.S. for 15 years after having spent a couple of years tweaking and auditioning different components and cables, etc. 

I am currently in Europe, and am developing a second system, and probably will make a couple of changes before settling in for the longer haul.

After a four-year process of upgrades, a process which started out fairly slowly, last year reached "fever pitch", I am just about "done" with upgrades for now.  As I learn more about room conditioning, I'll be installing some more bass traps, but I think (for now) I'm done with equipment upgrades.

I know that sounds strange to some of my audio buddies, the word "done", but I'm really happy with the performance of my system and until I get the hots to make changes (which is not at all likely, at least in the near future), I'll sit back and enjoy the beautiful sounds I've created!