I may be in the minority here but I strongly prefered the Vandy 1ci over the 2ce in two rooms in my house that are similar in size as yours. I made the mistake of thinking bigger is bettter. I suspect if you go with the 2's, the bass will quickly overload your room.
I also agree with the recommendation to take a road trip. If you come to NJ you can demo both the Vandy's at Audio Connection in Verona, NJ and the Ohms in Brooklyn, NY.
You will learn a lot in the process and be in a much better postion to gauge what you want.
Good luck!