Well, I've laid out a lot in the speaker thread, but I'm most fortunate and happy with my main 17' X 28' room.
My second room is 15' X 13', and has its challenges, as components tend to sound quite hard, and I often go through periods where component changes yield less difference than they should. I also have a third room, but I don't put as much effort into that
More than anything else, experience shows me the room takes the position as the most important component, by far