I think lowrider57 may be incorrect. The Mullards could be new production or old. The Yugoslavia 12AU 7's are definitely old stock. They haven't been inproduction for 20+ years. When this unit was first produced I don't think new production Mullards were available - my guess is that they are more probably old stock and I think that the NOS and new production do not have the same tonal qualities.
I'm not familar with your pre-amp but I suspect that the V1 and V2 positions are likely the positions most affected by tube changes. If that is so, and if I wanted to play with tubes changes, I would start there keeping in mind that different brands have different tonal qualities and it helps a lot in selecting tubes you want to try to have some 'tonal' goal and try tubes that have a similar tonal signature.
I'm not familar with your pre-amp but I suspect that the V1 and V2 positions are likely the positions most affected by tube changes. If that is so, and if I wanted to play with tubes changes, I would start there keeping in mind that different brands have different tonal qualities and it helps a lot in selecting tubes you want to try to have some 'tonal' goal and try tubes that have a similar tonal signature.