1 - Budget 10% to 20% of that on room acoustics.
2 - Brands, consider Monitor Audio, Revel, JBL, Focal, B&W. All different sounding.
3 - Also, think about what type of speaker.
- Full range?
- 2.5 way? (the size of the room may make this a good choice)
- Satellite + sub? Again, ideal for the size of the room PLUS allows subwoofer EQ without messing your main audio chain.
Would you consider a bespoke speaker system? Makers like Fritz can accommodate a wide range of customization, and components for not too much cash.