I repeat "it all depends"
I have amazed myself at suddenly I have found my mains supply is so rubbish. Not voltage variations but just contaminated and different at certain times of the day. I live in quite an upmarket town in UK so I do (did) not expect rubbish electricity!
An expert told me to try direct wall connection to amps (Bryston 7b3s into B&W800d3s) as with a conditioner (used by me for many years) there would be a lot of transformers and activity introduced in the process. An engineer also repeatedly told me there was no difference in cables, so advice is free and expensive! The result, by removing conditioners yet still having so called hi end cables, was that the sound became hugely weak and tinny, no depth or substance. and very unlistenable. I tried for a few days as I couldn't believe it - and also as I had sold my conditioners I had little option! Talk about disappointment! Anyway I found some US terminal conditioners (my conditioners are made by Airlink in Harlow UK, just 2 miles from me) and put those in. Fantastic - all the Bryston depth and quality returned in spades. I have also inserted a power regenerator at the processing end and when it arrives, I will insert instead of the conditioners at the amp end to sort the quality of power issue out and compare to the conditioners etc etc. I have no personal energy remaining to change power cables before the conditioners or regenerator, - but will in due course have a bash when I psyche myself up for more tests. PS Audio recommend a quality power cable BEFORE their regenerator. The people I sold the 2 UK Airlink conditioners to, reported significant improvements, one more than the other though.
Sorry I can only help with half the question at this stage