I am currently running my pair of STA 200s in vertical passive biamp mode, on a pair of not well known, Signet SL 280 ex floor standers ( a sleeper of a speaker, imo ). They are a two way, and was a competitor with speakers under the $1500. price point when they came out. I do use them with a powered sub, centered between them, in a 10 x 12 room, and the system sounds awesome. I run the amps passively ( no preamp ), and feel they would do very well with the Vandy 2Cs. The biwiring option is the 1st thing to do, as the Vandys / amp will definitely " open up ". Enjoy ! MrD.