Ears hurt when listening after changing speakers

Your room is getting over pressurized and  bass loaded. You can move them out into the room, or you can purchase a ton of bass busters. 

While auditioning several very good speakers a couple years back, I found that the more dynamic and revealing speakers, although impressive and gratifying at first, after a short time, did not set well with my ears.

This is a pet peeve of mine. There’s lots of ways to tweak or juice a speaker system, in the bass and the treble, which may make you feel like your ears are 20 years younger, but long term are tiring.

In some cases this is fine if you listen at low volume, but several designs rely on peaks and valleys in the tweeters to give this exaggerated treble.

It’s important to evaluate for a long time, and at the actual listening levels you listen at. If you are going to drive your Ferrari to/from the supermarket, that’s really the speed you test drive it at.

I feel some of the smaller Magico's tend to be more cool, but smooth. Dali has a big jump in tweeter level they use, and then I see B&W along with some GE designs use the tweeter peak and valley method.

Very good point Eric. With speakers, as well as everything else, one size doesn't fit all. 
As much as I would love a Ferrari, or even my old 67 muscle car Camaro, where I live now (notoriously bad roads and an abundance of dirt roads and primitive back roads) my 4x4 Chev. truck is much better suited.
While, for many years, I did attend about every genre of live performances - rock concerts, folk and country concerts, full orchestra and small venue jazz and blues performances - now, I'm quite content to set back in a quiet room with a cold brew and enjoy a long secession with my favorite tunes at somewhat more relaxed environment at a much lower volume. For that, for me, my little Maggies work incredibly well, but certainly not everyone's cup of tea.
As always - appreciate your knowledge and input....Jim  

I would add one more thing. The kind of fatigue you describe could also be caused by bad or shorted interconnects up stream, causing a real low hum. 

That beryllium dome could be making you a little jumpy. I had been a dealer for Merlin's until I realized that the Esotar tweeter was so bright I couldn't stand to listen.  Sold the demo's and discontinued the line. I never want to let a customer suffer through that or myself. 

Hmm. You think Dynaudio Esotar tweeters are bright? Never heard that before.