Any reason not to place stand mounted speakers upside down?

Some, like the Buchardt, are already upside down.

Any reason to place stand mounted speakers upside down?

Maybe: setting them up while drunk?  ;-)

I paired some old, small Tannoys (603) with an NAD D3020 in a traveling system. The speakers had been loaned to a friend and I had not listened to them for a couple of decades. After setting up the system 1500 mi from home,  I was not happy- harsh highs with a weirdly recessed midrange. Flipped them on a whim and the overall sound improved noticeably - more open, natural  midrange and smoother highs. My wife noticed the improvement and advocated leaving them “upside down” for the three month stay, (even though these speakers have a definite top and an unfinished plastic bottom).Your ear is the final arbiter.

Thanks for the anecdote, @returntomusic. As suggested previously, I'd love to use the old Osiris stands if possible, but if it doesn't work out, I can always buy a pair of correct (in terms of height) stands.

Hey wipsaw,

Some years ago, I purchased a pair of sight-unseen 24" Target stands for use with my Salk Veracity HT1s from an acquaintance who had them stored at his parent's house, instate.  They turned out to be 28" stands, so I faced the same dilemma.  Always helpful, Jim Salk saw no issues running them tweeter down and I was very pleased with the results.  Later, I've been able to right the system with a pair of Paradigm Ultracube 10v2 subwoofers beneath the Salks with IsoAcoustics ISA-L8R200 stands, carefully adjusting for height and tilt (arrival times.) 

The results in my little studio cube are quite spectacular...nearly 20 years of room tuning and sophisticated DSP...first, do no harm /// or, if minor harm be unavoidable, be certain that it is heavily outweighed by success.  The golden paradigm of "straight wire with gain" I've found to be a misnomer in the digital world.  After giving up a hard worked - full blown SOTA/Fidelity Research fx64/vacuum/electronic flywheel rig two decades ago, overall, this is decidedly better.  Good luck, wipsaw!  Happy tunes and More Peace.  Pinthrift