Top notch integrated vs DAC direct into stereo amp

My take is the simplest path is best. I’m currently listening to a Digital Amplifier Company (DAC) DAC 2 HSV (High Spec with Volume control) direct to a DAC 2 Cherry. This is about as pure a signal you can get and I’m really digging the results. No digital stress just sweet engaging sound on my horns. Large power supply in the amp and a highly filtered supply on the DAC provide an extremely low noise floor and the music flows through from the blackest background I’ve ever heard. 
https://www.cherryamp.com/

I have run the following iterations over the years:
DAC/pre/amp
Dedicated DAC to Integrated Amp
Dedicated DAC to amp w. software attenuation
Integrated DAC to amp 
(I even tried Integrated DAC to Integrated Amp, which as suspected, is not optimal)

Frankly, its stunning how much variance exists between such systems. 

The unvarnished truth; no one can tell you which would be better. You simply have to conduct comparisons. It becomes more interesting when swapping speakers, as often the combo that worked best with a given speaker will not be best with a different speaker.  I have one pair of speakers that works best with a $3.5K integrated DAC, and another pair that works best with a $10K integrated DAC, everything else in the rig being unchanged. 

It would take a lot of money and time to explore all the options, so most people simply select. Thankfully, you can get excellent results with any combination - depending upon the choice of components and cables. 

To make matters more complicated, if you select the "wrong", i.e. inferior amp, it matters not which combo you use in the system, you will never achieve a sound quality as good as when using a superior amp. Looks like you are aware of the necessity of an excellent amp.   :)

Well considering the level of gear here it will be impossible to home audition any of these combinations, will have to audition gear separately at dealer's.What would you guys pick between DAC into Audionet Humboldt vs DAC direct into Gryphon Mephisto stereo ?Speakers Borresen 03s.

DAC into integrated, any day of the year. I have not played at your level. But been trying to eliminate preamps forever it seems like, and I can’t. At your level, you are not short of funds, why would you, it doesn’t even make sense, given how much preamps can bring to the table. And at that price point you will get an integrated with a preamp stage that will be world class.