What sends shivers down your spine when you play it on your system?

Oh, there’s a bunch... but stand outs:

White Rabbit: Jefferson Airplane original vinyl
Time Out: mono version. (Whole album)
Camera Eye: Rush
Pretty much anything Pink Floyd

Lot’s of EDM gets it too. Many others...

1812 Overture - London Symphony Orchestra - possibly the most emotional piece of music ever written.

Telegraph Road - Dire Straights
La Villa Strangiato - RUSH
No Pussyfooting - Fripp & Eno
Dream Brother - Jeff Buckley
Genesis - Undertow
Blow at High Dough - The the Tragically Hip

To name a few

The final movement of the Copland Third Symphony.

+1 for Telegraph Road of Dire Straits (live). The guitar solo on this song (at about 4 min of the song) moves me like almost nothing else. It's a piece of art. Pure adrenaline.

Also the final guitar solo on Tunnel of love from them too. Incredible!