What sends shivers down your spine when you play it on your system?

Oxygène.   the sound just swirls all around me, like i am a mote in the eddies.

First one that comes to mind is the saxophone on Morphine's 'All Your Way' 

Oh, there’s a bunch... but stand outs:

White Rabbit: Jefferson Airplane original vinyl
Time Out: mono version. (Whole album)
Camera Eye: Rush
Pretty much anything Pink Floyd

Lot’s of EDM gets it too. Many others...

1812 Overture - London Symphony Orchestra - possibly the most emotional piece of music ever written.

Telegraph Road - Dire Straights
La Villa Strangiato - RUSH
No Pussyfooting - Fripp & Eno
Dream Brother - Jeff Buckley
Genesis - Undertow
Blow at High Dough - The the Tragically Hip

To name a few