What sends shivers down your spine when you play it on your system?

“The Ecstasy of Gold” orchestral intro on Metallica’s “S&M” CD. 
Oooo Mahler! Lots to revisit there!

Is that Mahler symphony 6 or 5?

I have that from Symphony 5 on a Classical
music for yoga and meditation CD. Giving it a streaming now.  Quite lovely and mellow yet encompassing. 

Mahler Symphony #3 is my favorite of the ones I know well. It transports me to an alternate state of mind throughout its duration.
Debussy's Deux Arabesques performed by pianist Philippe Entremont on a lousy-sounding old Masterworks LP.  The choral movement of Mahler's Third on an I-wish-it-sounded-slightly-better Jascha Horenstein recording I have  on both Nonesuch and Unicorn LPs.  Des Knaben Wunderhorn on Vanguard. Mike Garson's piano solo on Bowie's Aladdin Sane.
I think twoleftears meant Mahler 5, which I agree is absolutely beautiful.  Staying with Mahler, I agree with Mapman on Mahler 2, the final portion of the last movement always gives me the shivers.  As does the third movement of the Shostakovich 5th Symphony.
Ralph Vaughan Williams: Sinfonia Antartica

Also, The chimes at beginning of The Cures "Pictures of You"...
Eva Cassidy can bring tears to my eyes. 

The last movement of Mahler 2.

Sibelius Finlandia  sung acapella. 

Nessun Dorma from Turandot.
Vaughan Williams              "The Lark Ascending "              
Ramones -- I Wanted Everything.  Zeppelin -- Dazed and Confused.  Clapton's guitar solo in Spoonful, the one on Cream's "Wheels of Fire" album.  Judith Nelson's performance of Henry Purcell's "Pursuing Beauty" in Volume 2 of Henry Purcell's Theatre Music on L'Oiseau-Lyre.
Side 2 of Procul Harum's Shine On Brightly - "In Held 'Twas In I"! A 17 - minute masterpiece suite! A&M LP.
Any recording of the last movement of Mahler's First Symphony! I particularly like Ozawa/BSO on the DG LP.
Any recording of the last movement of the Saint Saens Symphony 3. I like Munch/BSO on RCA LP and Barenboim/CSO on DG.
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"Train To Nowhere" from Savoy Brown's Blue Matter. "Ride the wrong rails live your life in vain"!
"1983...Moon Turn The Tides Gently, Gently Away" from Hendrix's Electric Ladyland. Ditto "Burning Of The Midnight Lamp"! Hendrix as a science fiction visionary!
Btw people often ponder if you need a good hifi to enjoy music.  Probably not but definitely helps when in search of  shiver down your spine moments. 
Horrors!  Yes, typo, Mahler 5.  Must proof-read more carefully...
@newbee  If you don't already have it, the 2CD expanded version of Live at Blues Alley entitled Nightbird, to me sounds even better than the original release, plus there's a bunch of additional material. 
My first choice is Hugh Beam with Boult, the original conductor ." The Essential Vaughan Williams" on Warner classic

Very close is the great Scottish violinist  (never mind her name} Nicola Benedetti with Andrew Litton - forget the label but easy to find .

Iona Brown with Neville Marriner on Argo is also a heart breaker .
Dream Brother - Jeff Buckley
Satellites Lost - Delays
Musical Box - Genesis
Ana - Pixies
Black Flame - Renaissance
Two Step - Throwing Muses

+1 Balled of Dwight Fry
Star Wars Main theme Performed by the London Symphony orchestra & conducted by John Williams.
The 1st movement of Mahler 9.
Rachmaninoff “The Bells” 1st and 2nd movements (I have about 20 different versions of the piece.)
Brahms Cello Sonata #2, 4th movement.
Schubert Piano Sonata in Bb. D.960. (And much other Schubert.)
Anything by Eva Cassidy (Can’t help but tear up when she sings.)

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@dweller Totally agree - those chimes are amazing.@schubert Yes, such a beautiful tone poem. Absolutely sublime.
Art Pepper “Patricia” long version
Brubdck Quartet “Blue Rhondo” carnigie hall version 
John Coletrain “Summertime”
Sonny Stitt “Cleveland Blues”
Dr Lonnie Smith  “Backtrack”

Oxygène.   the sound just swirls all around me, like i am a mote in the eddies.
Oh, there’s a bunch... but stand outs:

White Rabbit: Jefferson Airplane original vinyl
Time Out: mono version. (Whole album)
Camera Eye: Rush
Pretty much anything Pink Floyd

Lot’s of EDM gets it too. Many others...
1812 Overture - London Symphony Orchestra - possibly the most emotional piece of music ever written.
Telegraph Road - Dire Straights
La Villa Strangiato - RUSH
No Pussyfooting - Fripp & Eno
Dream Brother - Jeff Buckley
Genesis - Undertow
Blow at High Dough - The the Tragically Hip

To name a few

+1 for Telegraph Road of Dire Straits (live). The guitar solo on this song (at about 4 min of the song) moves me like almost nothing else. It's a piece of art. Pure adrenaline.

Also the final guitar solo on Tunnel of love from them too. Incredible!
Nothing really sends shivers, but I think Grateful Dead's Ship of Fools comes close. Mostly because of the guitar solo at the end.

I am not a Grateful Dead fan. In fact, I find them boring and am baffled why people like them so much. This Ship of Fools must be some revenge of the Universe.
Roxy music/ avalon
jeff Buckley/ grace
pil/ album
bruce cockburn/ stealing fire
the cult/ love 
the church/ starfish. 
Lots of hard rock (noisy stuff for some ;-)) or straight up classical.. adding a mix from other kinds of sound:

- Rakim - Dead Can Dance
- Obvious People - Twin Shadow
- Future - Adam Beyer
- Safe From Harm - Massive Attack
- God’s Chariots - Oklou
- Bird of Paradise - Snowy White
- Hotel California - Eagles (the acoustic Unplugged version...that opening guitar solo!)
- Sonnet 138 - Ane Brun (Shakespeare put to gorgeous tune by Swedish Philharmonic)

Of course there many, but a real standout is

West Side Story/Prologue (from the original) 
barts -- I truly like my original Broadway Cast West Side Story, too.  The CD doesn't mention the conductor but I figure it's got to be Lenny.  Compelling score, performed with no end of compassion and energy.  Surprisingly good fidelity on my CD.
Oooops, how did I forget Santana’s Samba Pa Ti and Europa? Heaven's smile.
The Man That Got Away - Judy Garland
To Bobby - Joan Baez
Ben - Marti Webb
Born Free - Matt Monro
Yesterday When I Was Young - Roy Clark
Shine On You Crazy Diamond - Pink Floyd
2nd movement PC2 - Rachmaninoff

Since most of these are about loss (as well as being great performances) I'm not sure what to make of this list but none of them ever bring me down or lower my mood.

It might also seem sacrilegious to some, but I prefer the 5 min edit of Shine.

Maybe I like to think of them as occasionally necessary reminders of the sheer beauty of life. 
Duane and Dickey swapping solos on "Stormy Monday" on Live at Fillmore East.

Never heard two live back-to-back solos that were so amazing.  Those guys could sure play like they were inspired by something other-worldly.  Then again, most all music is pretty cool, so...

+1 No Yoko Ono.. I just broke out in cold sweat!!

Highwayman, Johnny Cash, Willie Nelson, Waylon Jennings, Kris Kristofferson. I love that song.

Rainmaker - Strunz & Farah (One of the BEST)

3. BIG fan of Pop music
4. Latin Jazz/Rock Carlos is just fine

I like Bali music. I know nothing about it. I just like to turn it up a bit.. I get the looks alright..

Country western
Island music
No! Yoko Ono

That's close.. not in that order.. LOL

Chrissie Hynde singing "There's a Thin Line Between Love and Hate" on the Pretenders Learning to Crawl LP. Gets me every time. Check it out.

John Coltrane's "A Love Supreme"

Aretha Franklin's heartfelt "Angel" written by her sister, off the Hey, Hey (The Other Side of the Sky) album. Of all Aretha's great albums,  this one song off one of later lesser records is so personal it always grabs me.

The Who; “Who’s Next”

David Bowie; “The Rise & Fall of Ziggy Stardust and the Spiders from Mars”

Bachman Turner Overdrive; “Not Fragile”