After he cashiered the original Mothers, Zappa tended to go back and forth between instrumental music and his day/night job of being a latter-day version of Doug Clark and the Hot Nuts. To the best of my knowledge (though often off the top of my head):
Essentially Instrumental:
Lumpy Gravy
Waka/Jawaka
The Grand Wazoo
Orchestral Favorites
London Symphony Orchestra Vol. 1, 2, 3
Boulez Conducts Zappa: The Perfect Stranger
Francesco Zappa
Some Vocals, Largely Instrumental
Uncle Meat
Burnt Weeny Sandwich
Weasels Ripped My Flesh
200 Motels
My favorites out of these would be Lumpy Gravy, Uncle Meat, Weasels Ripped My Flesh and Francesco Zappa. Many of the live recordings have long instrumental interludes.