Wyred 4 Sound vs. Roon Nucleus

The Roon Nucleus is a piece of hardware that Roon developed to specifically run their program.  I tried my Roon trial on an aging MacAir and the computer severely overheated when it got hung up trying to run the program so I can appreciate where a dedicated piece of hardware makes sense.  Otoh Roon is primarily a software company that doesn’t have a history designing audio components, unlike W4S.
  I’m not an IT guy but Roon is a large program that needs some computer firepower to work best  (I am basing this opinion on my limited trial and on the experiences that I have encountered here).  I think the one critical spec might be the RAM.  Roon specifies a minimum RAM and imo I would make sure the W4S at least doubles it.  Otherwise, if running Roon is the priority, and the choices are limited to the two that you have specified, I would go for the Nucleus

+1 on the Small Green Computer. Mine has only hung up a couple times. Generally very solid. Will run other media software programs as well.

Can the W4S DAC2v2SE act as a ROON endpoint? If not you gonna need one.
https://www.youtube.com/watch?v=I2WxKDAoVsA

If sound quality is your primary consideration, Roon may not be your best choice. By all accounts, Roon is wonderful for music file management, but other server/streamer setups using leaner (and quieter) software may sound better. Check out the A-gon thread by Grannyring describing the sound comparisons between Roon and the new software that runs on Innuos hardware. You may still decide that Roon's user interface is worth making some compromises in sound quality, but at least you'll be making decisions with eyes (and ears) wide open.

If sound quality is your primary consideration, Roon may not be your best choice.

Which brings up another question, what is your music source? Ripped files,music service , both?

Thinking of using Qobuz and/or Tidal as the primary source.