Can one use assymetric wire gauge for speaker cable construction?

Hello,

I am trying to build a DIY speaker cable, but while doing so I have one question that needs to be answered. I am using a cable which is essentialy made up of multuple individually insulated cables of smaller gauge.

So can I use more strands for the positive wire & lesser strands for negative wire, essentially an asymmetric gauge design. But length of both positive & negative wires will be same (and between left & right channel).

Can someone please help me answer this question?

Regards,

Saurabh