Looking for a Quality Desktop Solution

It also looks like the new LS50 is Roon certified so you could sell MRendu. That would be a sanitary setup.

Only negative is flexibility forfeit over separates.

The passive LS50 (what I have) is a little too big to be on a desktop. The new active one with DSP (and desktop setting I think) would be better, but then you do not need the Hegel 390.

The isoacustics stand are really a must for desktop speakers.

Amazon.com: IsoAcoustics Iso-Stand Series Speaker Isolation Stands with Height & Tilt Adjustment: Iso-155 (6.1” x 7.5”) Pair : Musical Instruments

Check this out ...

GR Research Desktop mini

Big buck sound for not a lot of money. Some assembly required

Add a small inexpensive sub and you you'll be able to update the dac and the amp and never want to leave your desk.

Thanks for all the suggestions. I hadn’t thought about speakers behind me but it would make great sense. I don’t have much room on my smallish desk which already has a laptop and second screen. If I put speakers on my desk, where would I throw my crap?

Right now I am considering something like the setup @arafiq shared, but just getting a small footprint integrated with a headphone output and skipping speakers for now.  I do have some good phones (Aeon Open and Focal Clear) that would be great to use at my desk.  Although I am going to try out the speakers behind me idea to see how that works for the future.