Since you’re considering ACS100 as primary digital source, the two obvious concerns are its non filtered & isolated USB output and external SMPS UPS power supply. If you’re ok with its external SMPS UPS power supply then all you need to ensure that your DAC has a decent to stellar USB implementation. Aurender uses low powered high efficiency CPU’s so they are designed for virtually no noise operation.
Alternatively if you can stretch your budget, consider buying a used ACS10. I have seen used ones available for $3500-$4K. With ACS10, you get all the functionality of ACS100 plus a high end audio streamer with a completely isolated & filtered USB output.
FWIW, I am using ACS100 in my system for ripping, storage and streaming. Since my DAC is Ethernet based, I am not relying on ACS100 USB output for audio. In my configuration, the ACS100 is virtually indistinguishable (to my ears) from previously owned N10 and N20. And then you have the Critical Listening Mode in ACS100 for even quieter, more transparent audio presentation.
Lastly, I must give props to Aurender for ACS Manager iOS app, its Metadata Editing and Library Management is simply outstanding. The transition (toggling) between ACS Manager app and Conductor app is seamless.
PS: My ‘Digital’ system is listed under my moniker if you like to see how I am using ACS100.