So many mentioned, many I want to explore now. A couple more to throw out, who couldn't be more different. First is Buckethead. Hard to put in a genre but most known for possibly "fastest" guitarist, appears alot with like of Claypool and Incubus/Praxis. Solo stuff super varied in styles. Try Electric Sea then Monsters and Robots.
Second is Tab Benoit. Funny, just saw at Falls Church Theater. Old school Fender sound, Delta/Zydeco blues. Tone just drips from his guitar. Loads of tube goodness! For blues, unusually large library of his own writing. Fever For The Bayou, Medicine.